Reversal of the adenosine triphosphate and adenosine diphosphate inactivation of liver fructose 1,6-diphosphatase by 3-phosphoglycerate.
نویسندگان
چکیده
ATP and ADP inactivate rabbit liver fructose 1,6-diphosphatase and change the nature of inhibition by AMP from sigmoidal to hyperbolic, with a concomitant increase in sensitivity to the inhibitor. 3-Phosphoglycerate both prevents and reverses the inactivation and restores the sigmoidal inhibition characteristics. The above kinetic behavior, which was observed with physiological concentrations of liver metabolites, together with the known upward flux in 3-phosphoglycerate concentration during gluconeogenesis may provide a possible physiological mechanism for regulation of liver fructose 1,6-diphosphatase activity.
منابع مشابه
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 246 6 شماره
صفحات -
تاریخ انتشار 1971